Barcelona, Paris St-Germain & Bayern keep up perfect starts
Romelu Lukaku made two and scored another as Napoli went top of Serie A with an impressive 4-0 win at Cagliari.
Premier League exports Scott McTominay and Billy Gilmour both came on as late substitutes for their debuts as Antonio Conte's side made it three wins from four.
Former Arsenal and Barcelona midfielder Cesc Fabregas was left frustrated after seeing a first Serie A win as head coach slip through his fingers.
Como, newly promoted to Serie A this season, squandered a two-goal lead to settle for a 2-2 draw with Bologna on Saturday.
An early own-goal by Nicolo Casale and a second-half finish by Patrick Cutrone from the edge of the box put them in control but late strikes by Santiago Castro and Samuel Iling-Junior rescued visitors Bologna.
"We had an important chance to win, we were solid but we have to be better at closing it out," Fabregas said.
"I have to do more to help the boys be more nasty in front of goal and close out the game."
Unbeaten Juventus were held to a 0-0 draw at Empoli but new AC Milan coach Paulo Fonseca got his first Serie A win in style as four goals before the half-hour mark saw them thrash Venezia 4-0.
Two quick penalties from former Chelsea duo Christian Pulisic and Tammy Abraham sealed the win.
Champions Inter missed the chance to go top, drawing 1-1 with Monza.